Precision EV Skincare, Clinician-Ready.
One flagship product. Uncompromising characterization. Built for the practitioners and researchers who demand more from a serum.
What Clinicians & Researchers Are Exploring
Extracellular vesicle (EV) and exosome-based skincare is one of the fastest-growing categories in aesthetic dermatology. Clinicians and researchers are actively exploring whether EV-derived serums may support what the field broadly calls next-generation anti-aging skincare — with proposed applications spanning cellular signalling support, skin renewal, and deep dermal delivery of bioactive compounds. Unlike conventional cosmetic serums that deliver isolated active molecules, EVs carry a multi-payload cargo of proteins, lipids, and nucleic acids within a phospholipid bilayer — a structural characteristic that many practitioners describe as a fundamentally different approach to delivering skincare actives. The growing body of preclinical research on cross-kingdom EV interactions has extended this clinical interest to plant-derived formulations, raising questions about scalability, safety, and standardization that BioThera Solutions was purpose-built to answer.
What Is the mPDEV Plant-Derived EV Serum by BioThera Solutions?
The mPDEV Serum by BioThera Solutions is a Health Canada-notified cosmetic containing plant-derived extracellular vesicles sourced from Aloe barbadensis, characterized to MISEV2023 standards. It is formulated with an ultra-minimal ingredient list — every component present by design — to preserve the biological activity of the EV payload through formulation and topical application.
A precision-formulated dermocosmetic serum — our first commercial application of the BioThera EV biomanufacturing platform.
Clinical Testing Phase — Early Access Only
The mPDEV (Exosome) Serum is currently in active clinical testing with selected dermatology partners — not available for general purchase. We are building the clinical evidence base this product deserves before broader deployment. Join the early access list to be notified the moment clinic access opens.
Aloe Barbadensis-Derived Extracellular Vesicles
~30 BILLION PARTICLES / mL · pH 5.5–6.0 · MISEV2023
Our flagship active is derived from Aloe barbadensis (aloe vera) — one of the most extensively studied medicinal plants in recorded history, with documented therapeutic use spanning thousands of years across cultures. Its safety profile is uniquely robust: aloe vera is classified as Generally Recognized As Safe (GRAS) by the FDA, is eligible for ECOCERT/COSMOS organic certification, and carries virtually no systemic toxicity risk when used topically.
BioThera's proprietary isolation process extracts EVs directly from fresh aloe vera plant material, yielding nanoparticles (30–200 nm) that preserve the plant's full bioactive cargo — antioxidant enzymes, anti-inflammatory polysaccharides, and wound-healing growth factors — within a stable phospholipid bilayer. At a guaranteed concentration of ~30 billion particles/mL, every application delivers a clinically meaningful, precisely dosed payload.
Full Formula (INCI)
6 ingredients. Every one intentional — nothing superfluous.
Ingredients / Ingrédients
Aloe Barbadensis-Derived Extracellular Vesicles, Glycerin, Sodium Hyaluronate, Phenoxyethanol, Ethylhexylglycerin, Gluconolactone, Sodium Benzoate, Sodium Phytate
Keep frozen until ready to use. Once opened, store at 4°C — use within 4 weeks. Do not refreeze.
Formulation Rationale
EVs as a multi-payload delivery system
Proteomics characterization of the mPDEV serum's EV fraction identified a large number of proteins distributed across three functional categories: antioxidant-associated, anti-inflammatory-associated, and wound-healing/regenerative-associated proteins. These protein classes are consistent with the well-documented biological profile of Aloe barbadensis, whose antioxidant, anti-inflammatory, and wound-healing properties have been studied extensively across decades of peer-reviewed literature. The EVs serve as the delivery vehicle for this protein cargo — encapsulated within a phospholipid bilayer that preserves the payload through formulation and application.
Dual-weight hyaluronic acid for layered hydration
We include both high-molecular-weight (HMW) and low-molecular-weight (LMW) Sodium Hyaluronate. HMW HA forms a moisture-retaining film at the skin surface, while LMW HA penetrates deeper layers to support structural hydration and improve the dermal matrix environment — directly synergizing with EV delivery kinetics.
Glycerin as a biocompatibility carrier
Glycerin's hygroscopic properties not only hydrate but maintain the stable aqueous microenvironment that preserves EV membrane integrity during application and absorption. Its universal tolerability makes it ideal for sensitive and post-procedure skin — key patient populations for the mPDEV serum.
Natural preservation without parabens
GSB Geogard Ultra (Gluconolactone + Sodium Benzoate) is a naturally-derived, ECOCERT/COSMOS-certified preservative system. Combined with Euxyl PE 9010 for broad-spectrum coverage, this dual approach ensures microbiological stability across the full shelf life — without the sensitization concerns linked to parabens.
Sodium Phytate for oxidative cargo protection
Plant-derived EVs carry bioactive lipids and proteins susceptible to metal-catalyzed oxidation. Sodium Phytate chelates trace metal ions within the formulation, shielding EV cargo from degradation and preserving active potency throughout the product's shelf life. ECOCERT/COSMOS certified, negligible sensitization risk.
pH buffered at 5.5–6.0 for skin compatibility
The formulation is buffered to pH 5.5–6.0 — closely matching the skin's natural acid mantle (pH 4.5–6.0). This range supports barrier integrity, minimizes transepidermal water loss, and creates optimal conditions for EV-membrane interaction at the skin surface. It also aligns with the native stability window of Sodium Hyaluronate and the preservation efficacy range of both preservative systems.
Allergy note: Individuals with a known sensitivity to aloe vera should perform a patch test prior to first use. Allergic contact dermatitis risk is low and consistent with the general aloe vera sensitization rate in the broader population (<1%). All other formulation ingredients carry a very low sensitization profile and are well-tolerated across skin types, including sensitive and compromised skin barriers.
Quality Documentation
Representative CoA Available on Request
A representative Certificate of Analysis for the mPDEV (Exosome) Serum — covering particle concentration, size distribution, viability, and sterility — is available to qualified partners and clinicians.
Pricing
Partner Pricing
Pricing is disclosed as part of our partner evaluation process — not listed publicly. Fill in the form below to join the waitlist and we will assess mutual fit before sharing commercial terms.
Is BioThera Solutions’s Plant-Derived EV Serum Health Canada Compliant?
The mPDEV Serum by BioThera Solutions is registered with Health Canada under the Cosmetic Notification process — the mandatory regulatory pathway for cosmetic products sold in Canada. BioThera Solutions characterizes its plant-derived EVs to MISEV2023 standards, the global consensus framework co-authored by the company's founder and established by the International Society for Extracellular Vesicles (ISEV).
Health Canada — Cosmetic Regulations (C.R.C., c. 869)
Fully compliant with Canada's Cosmetic Regulations under the Canada Consumer Product Safety Act (C.R.C., c. 869). Canadian market authorized.
MISEV2023 — Characterization Compliant
Fully compliant with the Minimal Information for Studies of Extracellular Vesicles (MISEV2023) guidelines — the global standard published by the International Society for Extracellular Vesicles (ISEV).
Leaping Bunny Cruelty-Free Certification
Active certification. No animal testing at any stage of production or supply chain.
FDA — FD&C Act / MoCRA Alignment
Formulation aligned with the Federal Food, Drug, and Cosmetic Act (FD&C Act, 21 U.S.C. § 361) and the Modernization of Cosmetics Regulation Act of 2022 (MoCRA). Facility registration in progress.
GMP/ISO-Aligned Manufacturing
Manufacturing process under active development toward GMP and ISO alignment in anticipation of therapeutic pipeline expansion.
Be First.
The mPDEV Serum is in active clinical evaluation — not yet in general distribution. Join the early access list and we will notify you the moment clinic access opens. Tell us who you are so we can prioritize the right pathway.